Hairloss Study Abstract: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review.

Hairloss Study Abstract: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review.

Title: 5 alpha-metabolism in finasteride-treated subjects and male pseudohermaphrodites with inherited 5 alpha-reductase deficiency. A review.
Title Abreviation: Eur Urol		Date of Pub: 1991
Author: Imperato-McGinley J;
Issue/Part/Supplement: -HEADING-	Volume Issue: 20 Suppl 1		Pagination: 78-81
MESH Headings: Aged; Androstenes (TU); Azasteroids (TU); Comparative Study; Double-Blind Method; Human; Male; Middle Age; Prostatic Hyperplasia (DT); Pseudohermaphroditism (DT/EN); Stanolone (ME); Testosterone 5-alpha-Reductase* (AI/DF/ME); -RN-;
Journal Title Code: ENM	Publication Type: CLINICAL TRIAL
Date of Entry: 920211N	Entry Month: 9204
Country: SWITZERLAND	Index Priority: 2
Language: Eng	Unique Identifier: 92104209
Unique Identifier: 92104209	ISSN: 0302-2838
Abstract: Male pseudohermaphrodites (MPHs) with inherited 5 alpha-reductase deficiency and decreased dihydrotestosterone production have a global defect in 5 alpha-metabolism affecting both C19 androgen metabolism and C21 steroid metabolism. However, the decreased 5 alpha-reduction of testosterone to dihydrotestosterone is the only impaired steroid conversion to have clinical consequences, e.g., ambiguous genitalia, impaired prostate differentiation and development, and decreased facial and body hair. The 5 alpha-steroid metabolite profile in the MPHs was compared with that of men with benign prostatic hyperplasia who were administered varying doses of the 5 alpha-reductase inhibitor finasteride. Finasteride was found to be a potent inhibitor of both C19 androgen and C21 5 alpha-steroid metabolism affecting both hepatic and peripheral 5 alpha-metabolism. The 5 alpha-steroid metabolite profile was strikingly similar to that of MPHs with inherited 5 alpha-reductase deficiency. The data suggest that a 5 alpha-reductase gene codes for an enzyme with affinity for multiple steroid substrates.
Abstract By: Author
Address: Department of Medicine, Cornell University Medical College, New York, NY.

Our Sponsors »

Order Propecia, Spectral DNC or Avodart online today from hair2go.com!

Is your natural treatment working for you? Or even working at all?
Advertorial
Why many natural oral supplements for hair loss have little effect on hair loss and why others do.